Researcher in therapeutic antibody development at SciLifeLab, DDD - Hiring in process/Finished, not possible to apply

Job description

The Science for Life Laboratory (SciLifeLab, www.scilifelab.se) is Sweden´s national infrastructure for molecular bioscience, with a mission to support academic research and drug development. The center combines advanced technical know-how and state-of-the-art equipment with a broad knowledge in translational medicine, e.g., through the SciLifeLab Drug Discovery & Development platform (SciLifeLab DDD, www.scilifelab.se/units/ddd-platform/). The SciLifeLab DDD platform is composed of several units with unique competencies related to drug discovery and development processes for both biologics and small molecules. These units are physically located in Stockholm, Uppsala, Gothenburg, and Lund and staffed by researchers employed at local universities. Typically, drug development projects run by the SciLifeLab DDD platform stem from academic basic science projects, in which opportunities to intervene with disease processes with either biologics, oligonucleotides, or small molecules have been identified and perceived to have commercial potential. A steering group prioritizes which projects receive support from the SciLifeLab DDD platform.

The Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH School) at KTH, is now looking to recruit a researcher to the Human Antibody Therapeutics (HAT) unit at SciLifeLab DDD in Stockholm.

The Human Antibody Therapeutics (HAT) unit at SciLifeLab DDD is an established and high-performing unit with a staff of six senior researchers, scientifically supported by three platform scientific directors (professor level). The unit has laboratories at both SciLifeLab campus in Stockholm, and at Medicon Village in Lund. The unit´s main responsibility is to drive the SciLifeLab DDD antibody drug discovery programs in collaboration with other competencies from the whole SciLifeLab DDD infrastructure (approx. 45 employees) as well as academic principal investigators (PIs). An essential component for this work is several in-house developed phage-display human antibody libraries with proven ability to deliver high-affinity binders to targets of interest for further development into therapeutic antibody candidates. The unit is also responsible for other in vitro selection-based methods such as DNA-encoded chemical libraries for the discovery of small molecule drug candidates.

The main part of the work includes in vitro selection using phage display of human recombinant antibodies intended for medical therapy, as well as antibody characterization using various binding assays. The work also includes documentation in ELN, as well as writing reports on performed analyzes and experiments.

Protein and antibody production in bacteria and mammalian cells, as well as purification and characterization, including purity, stability, aggregation, etc., may also be included. Furthermore, in vitro selection from DNA encoded chemical libraries may also be included.

What we offer

• A position at a leading technical university that generates knowledge and skills for a sustainable future.
• Engaged and ambitious colleagues along with a creative, international and dynamic working environment.
• Work in Stockholm , in close proximity to nature.
• Help to relocate and be settled in Sweden and at KTH

Read more about what it is like to work at KTH

Qualifications

Requirements

• A doctoral degree, or an equivalent foreign degree, in biotechnology, cell or molecular biology, biochemistry, biophysics, or immunology.
• Solid practical experience of molecular biological work, incl. DNA techniques (PCR, cloning, transformation, etc.).
• Solid practical experience in phage display selection of recombinant antibodies or other binding proteins.
• Solid practical experience of analysis methods for characterization of binding, such as ELISA and SPR.
• Excellent ability to communicate in English, both orally and in writing since this is needed for the position.
• We believe you have great research expertise as well as great teaching abilities. We appreciate your ability to work towards research results and has been utilized in practice.
• Furthermore we see that you have the ability to inform about research and development work as well as experience of developing and leading activities and staff.

Preferred qualifications

• Experience in alternative in vitro display techniques in addition to phage display.
• Experience in recombinant protein or antibody production, purification and characterization.
• Experience of working within the biotech/pharmaceuticals industri.
• Experience in AI, machine learning and similar technology.
• Experience in project management.
• Knowledge of diversity and equal opportunity issues, with specific focus on gender equality. 

Great emphasis will be placed on personal competency. and in addition to the mentioned qualifications above, a successful candidate is also expected to meet the following requirements: 

• Excellent team work ability and the ability to meet requests from external stakeholders with a goal and results-oriented focus.
• Excellent problem-solving analytical ability with an independent, structured and thorough way of working.
• High degree of integrity, motivation and flexibility at work.

Great emphasis will be placed on personal competence.

Trade union representatives

You will find contact information to trade union representatives at KTH's webbpage.

Application

Log into KTH's recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad. Your complete application must be received at KTH no later than the last day of application.

Your complete application must be received by KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time). 

About the employment

The employment is valid until further notice (permanent post) according to agreement.
The employment begins with a six-month probationary period.

Other information

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence