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Single-particle cryogenic electron microscopy (cryo-EM) is a tomographic method for computationally recovering the 3D structure of a biomolecule from electron microscope imaging data, which is having profound impact on structural biology in general, and drug design in particular. Current 3D reconstruction methods only work for quite rigid biomolecules but these molecules often have inherent flexibility that is of interest in structural biology as changes in the atomic structure are crucial in determining function. This postdoctoral research project will focus on developing data-driven priors of atomic models using domain-adapted neural networks trained on simulations obtained from molecular dynamics. These priors will then be used to estimate entire atomic model trajectories given cryo-EM data.
This position is part of a joint collaboration between the two largest research programs in Sweden, the Wallenberg AI, Autonomous Systems and Software Program (WASP) and the SciLifeLab and Wallenberg National Program for Data-Driven Life Science (DDLS), with the ultimate goal of solving ground-breaking research questions across disciplines.
Wallenberg AI, Autonomous Systems and Software Program (WASP) is Sweden’s largest individual research program ever, a major national initiative for strategically motivated basic research, education and faculty recruitment. The program addresses research on artificial intelligence and autonomous systems acting in collaboration with humans, adapting to their environment through sensors, information and knowledge, and forming intelligent systems-of-systems. The vision of WASP is excellent research and competence in artificial intelligence, autonomous systems and software for the benefit of Swedish industry. Read more: https://wasp-sweden.org/.
The SciLifeLab and Wallenberg National Program for Data-Driven Life Science
(DDLS) is a 12-year initiative that focuses on data-driven research, within fields essential for
improving the people ́s lives, detecting and treating diseases, protecting biodiversity and creating
sustainability. The programme will train the next generation of life scientists and create a strong
computational and data science base. The program aims to strengthen national collaborations
between universities, bridge the research communities of life sciences and data sciences, and create partnerships with industry, healthcare and other national and international actors. Read more:
https://www.scilifelab.se/data-driven
Read more about what it is like to work at KTH
Requirements
Preferred qualifications
Great emphasis will be placed on personal competency.
You will find contact information to trade union representatives at KTH's webbpage.
Log into KTH's recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad.
The application must include:
Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).
The position offered is for, at the most, two years.
A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.
Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.
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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.
Type of employment | Temporary position |
---|---|
Contract type | Full time |
First day of employment | According to agreement |
Salary | Monthly salary |
Number of positions | 1 |
Full-time equivalent | 100% |
City | Stockholm |
County | Stockholms län |
Country | Sweden |
Reference number | S-2022-0743 |
Contact |
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Published | 05.Apr.2022 |
Last application date | 31.May.2022 |