Postdoc in computational biophysics - Hiring in process/Finished, not possible to apply

Job description

Sugar transporters (GLUTs) have the fundamental role to take up energy into cells in the form of glucose and other hexoses; they belong to the MFS superfamily and follow a rocker-switch alternating access model of transport. Due to their ubiquitous nature and their overexpression in cancer cells, GLUTs are important targets for drug design. Yet, while multiple structures have been resolved, their dynamic nature and the distinct relative stability of different states in related isoforms only allow for a poor resolution of the different steps along the transport cycle. 
Recent work on bacterial sugar transporters has revealed an imperfect proton coupling in proteins previously believed to be passive transporters, suggesting that the destabilization of intermediate states is at the core of the substrate:proton coupling. The aims of this project are to characterize the proton-coupling mechanism affecting GLUTs dynamics, its and allosteric regulation by small molecule inhibition.
The postdoc candidate will carry out computational work, using mainly molecular dynamics simulations, including but not limited to enhanced sampling simulations and constant pH. Results from this work will be tested by our collaborators in the Drew lab at Stockholm University.

What we offer

• A position at a leading technical university that generates knowledge and skills for a sustainable future
• Engaged and ambitious colleagues along with a creative, international and dynamic working environment
• Work in Stockholm, in close proximity to nature
• Help to relocate and be settled in Sweden and at KTH

Read more about what it is like to work at KTH

Qualifications

Requirements

• A doctoral degree or an equivalent foreign degree. This eligibility requirement must be met no later than the time the employment decision is made.
• Experience with molecular dynamics simulations
• Experience working in collaborative work environments
• Research expertise
• Awareness of diversity and equal opportunity issues, with specific focus on gender equality
• Collaborative abilities
• Independence

Preferred qualifications

• A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline, (with some exceptions for special reasons such as periods of sick or parental leave, kindly indicate if such reason exists in your resume).

• Teaching abilities
• Experience with enhanced sampling simulations
• Experience with biological systems, including membrane proteins

Great emphasis will be placed on personal competency.

Trade union representatives

You will find contact information to trade union representatives at KTH's webbpage.

Application

Log into KTH's recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad.

The application must include:

1. CV including relevant professional experience and knowledge.
2. Brief account of why you want to conduct research, your academic interests and how they relate to your previous studies and future goals. Max two pages long.

Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).

About the employment

The position offered is for, at the most, two years.

A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Others

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.