Postdoc in cell-line engineering for viral vector manufacuring - Hiring in process/Finished, not possible to apply

Job description

Gene therapies based on viral vectors are currently on the rise with several new approvals or therapies based on Adenoassociated viruses (AAVs) in recent years. However, a major bottleneck with these drugs are that they are difficult to produce and bioproduction often result in a low degree of capsids filled with the therapeutic transgene. This makes the manufacturing expensive and unsustainable. We are looking for a doctoral student who will work with the mapping of the cellular landscape during AAV bioproduction to understand what host proteins are interacting with the viruses and impacting the packaging and release of the viruses from the cells. The person we are looking for will work with methods related to viral vector production in mammalian cells as well as analysis and purification of viral particles. The project will include methods such as RNAseq analysis, molecular cloning, immunoprecipitation, confocal microscopy, ELISA and western blotting. We are looking for a person that is driven and has a great analytical capacity.

What we offer

• A position at a leading technical university that generates knowledge and skills for a sustainable future
• Engaged and ambitious colleagues along with a creative, international and dynamic working environment
• Work in Stockholm, in close proximity to nature
• Help to relocate and be settled in Sweden and at KTH

Read more about what it is like to work at KTH

Qualifications

Requirements

• A doctoral degree or an equivalent foreign degree. This eligibility requirement must be met no later than the time the employment decision is made.
• We are looking for a person with good scientific and problem-solving skills and with a high degree of scientific integrity
• You are experienced in mammalian cell handling and cultivation
• You have good knowledge and experience in different molecular biological methods

Personal skills

• As a person you work in a structured and responsible manner
• You have good collaborative abilities but is also able to work independently

Preferred qualifications

• A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline
• Knowledge and experience in bioinformatics and programming
• Expertise in biotherapeutics and viral vectors for gene therapy applications
• Experience in working with or producing viral vectors
• Experience in molecular biotechnological methods such as RNAseq analysis, molecular cloning, immunoprecipitation, confocal microscopy, ELISA and western blotting
• It’s commendable if you have teaching abilities
• We prefer that you are aware of diversity and equal opportunity issues, with specific focus on gender equality

Great emphasis will be placed on personal skills.

Trade union representatives

You will find contact information to trade union representatives at KTH's webbpage.

To apply for the position

Log into KTH's recruitment system in order to apply for this position. You are the main responsible to ensure that your application is complete according to the ad.

Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).

About the employment

The position offered is for, at the most, two years.

A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Others

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.