Doctoral student (licentiate) in omics evaluation of cell models - Hiring in process/Finished, not possible to apply

Project description

Third-cycle subject: Biotechnology

Technological development, allows generation of cell models for different organs and by carrying different genetic mutations mimic different disease forms that are representative for the patient population. Such cell models enable studies at the molecular level otherwise impossible to conduct and constitute a biological system suitable for developing and testing the effect of new therapies on individual cells. Understanding how different genetic mutations affect for example the heart's function can be accomplished by creating and studying such models. The need of cell models is evident for rare monogenic disease, like muscular dystrophies. These diseases often affect children, are incurable and characterized by increasing muscle breakdown, breathing difficulties and ultimately heart failure.

The purpose of this project is to evaluate patient-representative cell models for muscular dystrophies by investigating how biological processes are affected by mutations in disease-relevant genes. The project will focus on creating and studying cell models for skeletal muscle and heart. Technological platforms will be used to analyze RNA and proteins, to evaluate how well the cell models mimic the tissues and how the disease varies between patients. The results of the project will eventually improve the development and testing of new drugs including cell therapies.

Supervision: Cristina Al-Khalili Szigyarto is proposed to supervise the doctoral student. Decisions are made on admission

What we offer

• The possibility to study in a dynamic and international research environment in collaboration with industries and prominent universities from all over the world. Read more
• A workplace with many employee benefits and monthly salary according to KTH’s Doctoral student salary agreement.
• A postgraduate education at an institution that is active and supportive in matters pertaining to working conditions, gender equality and diversity as well as study environment.
• Work and study in Stockholm, close to nature and the water.
• Help to relocate and be settled in Sweden and at KTH.
• Participation in a multidisciplinary research project aimed at developing methods for creating and evaluating cell models.

Admission requirements

To be admitted to postgraduate education (Chapter 7, 39 § Swedish Higher Education Ordinance), the applicant must have basic eligibility in accordance with either of the following:

• passed a second cycle degree (for example a master's degree), or
• completed course requirements of at least 240 higher education credits, of which at least 60 second-cycle higher education credits, or
• acquired, in some other way within or outside the country, substantially equivalent knowledge

In addition to the above, there is also a mandatory requirement for English equivalent to English B/6, read more here

Selection

In order to succeed as a doctoral student at KTH you need to be goal oriented and persevering in your work. During the selection process, candidates will be assessed upon their ability to:

• independently pursue his or her work
• collaborate with others,
• have a professional approach and
• analyse and work with complex issues.
• Generation of cell models is central to the project and documented knowledge and experience of cell cultivation and sterile work is meritorious. In addition knowledge about rare neuromuscular diseases, e.g. dystrophinopathies, is also meritorious.

After the qualification requirements, great emphasis will be placed on personal competency. 

Target degree: Licentiate degree

Information regarding admission and employment

Only those admitted to postgraduate education may be employed as a doctoral student. The total length of employment may not be longer than what corresponds to full-time doctoral education in four years ' time. An employed doctoral student can, to a limited extent (maximum 20%), perform certain tasks within their role, e.g. training and administration. A new position as a doctoral student is for a maximum of one year, and then the employment may be renewed for a maximum of two years at a time. In the case of studies that are to be completed with a licentiate degree, the total period of employment may not be longer than what corresponds to full-time doctoral education for two years.

Union representatives

You will find contact information for union representatives on KTH's website.

Doctoral section (Students’ union on KTH Royal Institute of Technology)

You will find contact information for doctoral section on the section's website.

To apply for the position

Apply for the position and admission through KTH's recruitment system. It is the applicant’s responsibility to ensure that the application is complete in accordance with the instructions in the advertisement.

Applications must be received at the last closing date at midnight, CET/CEST (Central European Time/Central European Summer Time).

Applications must include the following elements:

• CV including your relevant professional experience and knowledge.
• Application letter with a brief description of why you want to pursue research studies, about what your academic interests are and how they relate to your previous studies and future goals. (Maximum 2 pages long)
• Copies of diplomas and grades from previous university studies and certificates of fulfilled language requirements (see above). Translations into English or Swedish if the original document is not issued in one of these languages.Copies of originals must be certified.
• Representative publications or technical reports. For longer documents, please provide a summary (abstract) and a web link to the full text.

Other information

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

The position may include security-sensitive activities. To become authorized, you therefore need to pass a possible security check.

We firmly decline all contact with staffing and recruitment agencies and job ad salespersons.

Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.