Researcher Biologics Drug Discovery at the DDD platform

Job description

The Drug Discovery & Development platform at the Science for Life Laboratory (SciLifeLab DDD) is a national infrastructure for academic drug development with the task of translating academic discoveries into drug candidates for further commercial development. The business, which has existed for almost ten years, has, among other things, contributed to >10 new companies and four clinical drug candidates. The platform includes around 40 employees at six Swedish universities who all support collaborative projects with external academic project owners.

The DDD unit "Therapeutic Protein Engineering" (TPE) is attached to KTH and located at SciLifeLab DDD, Solna. The unit's main responsibility is to deliver well-characterized antibodies, antigens, and target proteins to the projects, as well as be technically responsible for the selection-based projects.

Your tasks will be to do phage display selection of antibody fragments to therapeutic targets, with the aim to develop protein based drugs. You will express and purify binders and analyze their binding in assays and using various established methods. Your tasks will be predominantly lab-based, and you will work as a member of different project teams with the aim to deliver drug candidates.

What we offer

• A position at a leading technical university that generates knowledge and skills for a sustainable future.
• Engaged and ambitious colleagues along with a creative, international and dynamic working environment
• Work in Stockholm , in close proximity to nature
• Help to relocate and be settled in Sweden and at KTH

Read more about what it is like to work at KTH.

Qualifications

Requirements

• PhD or equivalent in biotechnology, biochemistry or molecular biology
• Phage display selection of antibody fragments or other scaffolds
• Screening of binders using ELISA or SPR
• Thorough knowledge of standard protein analysis methods
• Standard molecular biology, e.g. cloning, PCR, mutagenesis
• Protein purification and analysis, e.g. western blot
• Expression of proteins in E.coli 

Preferred qualifications

• Experience from biotech/pharmaceutical industry or relevant academic research environment
• Construction of phage libraries, or other libraries
• Affinity maturation
• Biophysical protein analysis methods, e.g. CD spectroscopy, DLS and DSF
• Transient expression of proteins in mammalian cells
• Protein purification using ÄKTA systems or similar systems
• Experience with protein engineering
• Excellent writing and communication skills
• Project management and coordination
• Knowledge of diversity and equal opportunity issues, with specific focus on gender equality 
• Good collaborative abilities and a high level of independence

Great emphasis will be placed on personal skills.

Trade union representatives

Contact information to trade union representatives.

To apply for the position

Log into KTH's recruitment system in order to apply for this position. You are responsible to ensure that your application is complete according to the instructions in the ad. Your complete application must be received at KTH no later than the last day of application.

The application must contain:

1. CV including relevant professional experience and knowledge.
2. Copy of diplomas and grades from your previous university studies. Translations into English or Swedish if the original documents are not issued in either of these languages.
3. Personal letter (1 page)

Your complete application must be received by KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time). 

About the employment

The employment is valid until further notice (permanent post) according to agreement.
The employment begins with a six-month probationary period.

Other information

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process.

According to The Protective Security Act (2018-585), the candidate must undergo and pass security vetting if the position is placed in a security class. Information regarding whether the position is subject to such a classification will be provided during the recruitment process.

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Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence